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pentobarbital will minimize the level or effect of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Use of naloxegol with sturdy CYP3A4 inducers just isn't advisablepentobarbital will lessen the level or effect of sunitinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.Check Carefu